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  • Causes of increased D-dimer - acute care testing

    Application of the test in this way allows rapid exclusion of VTE without the necessity for expensive, time-consuming imaging tests. The low specificity of a positive D-dimer for VTE is strikingly highlighted by a recently published retrospective clinical study focusing on the use of D-dimer testing in an emergency department setting.

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  • D-Dimer - Health Encyclopedia - University of

    What is this test? This is a blood test to look for a substance called D-dimer. This test is used to rule out a blood clot. D-dimer is a protein fragment from the break down of a blood clot. Blood clots generally start to slowly break down after they are formed, and this process releases D-dimer into the blood. Why do I need this test?

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  • Widely Used Types and Clinical Applications of D

    2016-5-1 · In contrast with a negative D-dimer result, a positive D-dimer assay result is nonspecific and can be caused by many diseases. A large retrospective study of 1647 patients, evaluated at a large urban medical center, whose specimens yielded a positive D-dimer result showed infection as the most common cause, followed by VTE, syncope, heart failure, trauma, and cancer.

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  • Never ignore extremely elevated D-dimer levels: they

    Methods: Retrospective cohort study of patients > 18 years with an extremely elevated (> 5000 μg/l; > 10x cut-off to exclude VTE) D-dimer test result. Electronic medical records were reviewed for diagnoses. Results: A total of 759 extremely elevated D-dimer results were identified. After exclusion of 120 duplicate cases, 53 patients undergoing cardiopulmonary resuscitation, and 5 cases without diagnostic …

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  • D-dimer test, normal D-dimer level and elevated D

    A D-dimer result is unhelpful when the pretest probability of VTE is “likely” for three reasons: (i) the result is unlikely to be negative even if VTE is not present (ie many of the factors that increase the risk of VTE will also increase D-dimer levels, eg cancer, recent surgery); (ii) a positive result still requires confirmatory imaging; and (iii) there is uncertainty that D-dimer testing can safely exclude VTE in this subgroup.

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  • Review of D‐dimer testing: Good, Bad, and Ugly -

    2020-4-20 · There are two main types of D-dimer assays, each reporting different D-dimer units (see Table 1). The Fibrinogen Equivalent Unit (FEU) reports D-dimer levels based on the molecular weight of fibrinogen (340kDa), whereas the D-Dimer Unit (DDU) reports D-dimer levels based on its own molecular weight (195kDa), which is about half that of fibrinogen.

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  • COVID-19 and D-dimer - Hematology.org

    2015-1-1 · The finding of a D-dimer below the threshold published in the package insert can be used safely, but because of rising values, the test was below the threshold in patients without VTE in 50%, 22%, and 0% in patients in the first, second, and third trimesters, respectively; thus, there is an increased false positive value of the test, a problem that increases with the progression of the pregnancy along …

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  • D-dimer: An Overview of Hemostasis and Fibrinolysis ...

    2020-12-2 · In patients where DVT is suspected and when the two-level DVT Wells score is ‘unlikely’ (≤ 1 point), a D-dimer test is recommended, with a proximal leg vein ultrasound performed if the D-dimer test result is positive . Similarly, patients with suspected PE should be …

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  • Point-of-Care Testing for D-Dimer in the Diagnosis of ...

    However, although the D-dimer test could be used as an exclusionary test to rule out DVT when a normal D-dimer test result is obtained, the test is not helpful in cancer patients (which is not different from noncancer patients) to prove DVT in case of a positive or abnormal test result, given the low positive predictive value of 56% (95% CI, 48%-63%).

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  • Anti-D-dimer Antibodies | Invitrogen

    Antibodies that detect D-dimer can be used in several scientific applications, including ELISA, Western Blot, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen) and Immunocytochemistry. These antibodies target D-dimer in Mouse, Human and Canine samples. Our D-dimer monoclonal and polyclonal antibodies are developed in Mouse and Rabbit.

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  • D-dimer: An Overview of Hemostasis and Fibrinolysis ...

    2015-1-1 · The finding of a D-dimer below the threshold published in the package insert can be used safely, but because of rising values, the test was below the threshold in patients without VTE in 50%, 22%, and 0% in patients in the first, second, and third trimesters, respectively; thus, there is an increased false positive value of the test, a problem ...

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  • D-dimer test, normal D-dimer level and elevated D

    2020-9-22 · make the use of serum D-dimer an unacceptable screening test in the diagnosis of VTE in patients within 28days of TKR. With 96% of patient’shaving a positive D-dimer and only 4% (at 99days and 143 days post operatively) having a negative D-dimer, it would seem that in the vast majority of cases, the test

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  • Serum D-dimer should not be used in the diagnosis of ...

    2020-4-20 · However, D-dimer has low specificity as there are many other conditions with ongoing activation of the hemostatic system in which D-dimer can be elevated such pregnancy, inflammation, malignancy, trauma, liver disease (decreased clearance), heart disease, sepsis or as a result of hemodialysis, CPR or recent surgery.

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  • COVID-19 and D-dimer - Hematology.org

    A false positive test result (in case of pregnancy, liver diseases, etc.) may show up, thus misleading someone regarding his D-dimer normal range. A false negative test, on the other hand, may be seen if the blood sample is taken too early after there is a thrombus formation, or if testing for the same has been delayed by many days.

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  • Point-of-Care Testing for D-Dimer in the Diagnosis of ...

    2019-11-18 · Similarly, D-dimer is found to be a very valuable test in pregnant patients; if a pregnant woman has a low pretest probability for DVT, the NPV of a negative D-dimer test result is 100%. Since D-dimer assumes activation of the coagulation and fibrinolytic systems, it is valuable in the diagnosis and the monitoring of DIC in combination with ...

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  • D-dimer Normal Range - Health Hearty

    2013-5-3 · A negative D-dimer test can rule out venous thromboembolism in patients with a non-high clinical probability. Since D-dimer levels increase with age, the proportion of false positive D-dimer test results for venous thromboembolism using conventional cut-off values (500 µg/L) increases in older patients and the specificity decreases

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  • D-Dimer: Reference Range, Interpretation, Collection

    Here is a scatter plot of the data. Each of the individual measurements for each sample are plotted. The x-axis is the expected concentration of D-dimer for each sample, and the y-axis is. the measured concentration. A linear regression line with a slope of 0.992 and intercept of - 0.001 was fit to the points.

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  • Anti-D-dimer Antibodies | Invitrogen

    Antibodies that detect D-dimer can be used in several scientific applications, including ELISA, Western Blot, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen) and Immunocytochemistry. These antibodies target D-dimer in Mouse, Human and Canine samples. Our D-dimer monoclonal and polyclonal antibodies are developed in Mouse and Rabbit.

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  • D-Dimer Test: MedlinePlus Medical Test

    2021-6-10 · A D-dimer test is most often used to find out whether you have a blood clotting disorder. These disorders include: Deep vein thrombosis (DVT), a blood clot that's deep inside a vein. These clots usually affect the lower legs, but they can also happen in other parts of the body. Pulmonary embolism (PE), a blockage in an artery in the lungs.

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  • Colorimetric detection of D-dimer in a paper-based ...

    Using an appropriate dilution, the test could be used to yield positive results only for those samples with a D-dimer concentration above the clinically relevant threshold range of 250-500 ng/mL.

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  • Stago - Detail - STA®-Liatest® D-Di Plus, Less ...

    Select the best D-Dimer test for cost-effectiveness and safety. STA® -Liatest® D-Di has been clinically validated in outcome studies of over 4,000 patients with suspected DVT and PE to be used to safely aid in the diagnosis of VTE. Using the 0.5 μg/mL (FEU) threshold in conjunction with a pre-test probability assessment, the STA® -Liatest ...

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  • D-dimer as a biomarker for disease severity and

    2020-7-10 · The distributions of D-dimer levels among patients with different clinical staging, chest CT staging, and who survived and deceased during hospitalization are presented in Figs. 1, 2, 3, and 4.On admission, D-dimer levels significantly increased with increasing severity of COVID-19 as determined by clinical staging (Kendall’s tau-b = 0.374, P = 0.000), chest CT staging (Kendall’s tau-b = 0 ...

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  • D-dimer Normal Range - Health Hearty

    A false positive test result (in case of pregnancy, liver diseases, etc.) may show up, thus misleading someone regarding his D-dimer normal range. A false negative test, on the other hand, may be seen if the blood sample is taken too early after there is a thrombus formation, or if testing for the same has been delayed by many days.

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  • Do Normal D-dimer Levels Reliably Exclude Cerebral

    2004-10-28 · The D-dimer levels (mean±SD) were significantly higher in patients with CST than in patients in whom CST could be excluded (2052±1286, 375±368, respectively; P <0.0001). From the 35 neuroradiologically proven CST cases, there was only 1 (2.8%) who had a normal D-dimer …

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  • A cohort study of 676 patients indicates D-dimer is a ...

    2020-11-9 · D-dimer has the highest C-index to predict in-hospital mortality, and patients with D-dimer levels ≥0.5 mg/L had a higher incidence of mortality (Hazard Ratio: 4.39, P<0.01). Our study suggested D-dimer could be a potent marker to predict the mortality of COVID-19, which may be helpful for the management of patients.

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  • The DiPEP study: an observational study of the

    2018-5-21 · Sensitivities and specificities of D-dimer were 88.4% and 8.8% using a standard threshold and 69.8% and 32.8% using a pregnancy-specific threshold. Conclusions. Clinical decision rules and D-dimer should not be used to select pregnant or postpartum women …

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  • Recognising bias in studies of diagnostic tests part 2 ...

    Multiple pitfalls can occur with the conduct and analysis of a study of diagnostic tests, resulting in biased accuracy. Our conceptual model includes three stages: patient selection, interpretation of the index test and disease verification. In part 2, we focus on (1) Interpretation bias (or workup bias): where the classification of an indeterminate index test result can bias the accuracy of a ...

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  • D-dimer: Simple Test, Tough Problems | Archives of ...

    2013-8-1 · Context.—D-dimer is widely used for exclusion, or as an aid in diagnosis, of venous thromboembolism (VTE); however, the D-dimer assay methods available from manufacturers and the laboratory application of those methods vary widely.. Objectives.—To describe the current laboratory practice regarding the assay and reporting of D-dimer.. Design.—Laboratories' D-dimer proficiency …

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  • Anti-D-dimer Antibodies | Invitrogen

    Antibodies that detect D-dimer can be used in several scientific applications, including ELISA, Western Blot, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen) and Immunocytochemistry. These antibodies target D-dimer in Mouse, Human and Canine samples. Our D-dimer monoclonal and polyclonal antibodies are developed in Mouse and Rabbit.

    Get Price
  • How we diagnose and treat deep vein thrombosis |

    2002-5-1 · In general, a positive D-dimer result is not useful because the test lacks specificity. D-dimer levels are elevated not only in the setting of acute thrombosis, but also in other conditions such as pregnancy, infection, and malignancy. In contrast, a negative result using a sensitive D-dimer test is useful for excluding acute DVT.

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  • D-dimer: An Overview of Hemostasis and Fibrinolysis ...

    2015-1-1 · The finding of a D-dimer below the threshold published in the package insert can be used safely, but because of rising values, the test was below the threshold in patients without VTE in 50%, 22%, and 0% in patients in the first, second, and third trimesters, respectively; thus, there is an increased false positive value of the test, a problem ...

    Get Price
  • D-dimer as a biomarker for disease severity and

    2020-7-10 · The distributions of D-dimer levels among patients with different clinical staging, chest CT staging, and who survived and deceased during hospitalization are presented in Figs. 1, 2, 3, and 4.On admission, D-dimer levels significantly increased with increasing severity of COVID-19 as determined by clinical staging (Kendall’s tau-b = 0.374, P = 0.000), chest CT staging (Kendall’s tau-b = 0 ...

    Get Price
  • Diagnostic accuracy of conventional or age adjusted D ...

    2013-5-3 · A negative D-dimer test can rule out venous thromboembolism in patients with a non-high clinical probability. Since D-dimer levels increase with age, the proportion of false positive D-dimer test results for venous thromboembolism using conventional cut-off values (500 µg/L) increases in older patients and the specificity decreases

    Get Price
  • Ultrasound for Lower Extremity Deep Venous Thrombosis

    a clinical decision rule assessment, a negative D-dimer test is adequate to safely exclude DVT. Venous ultra-sound is not appropriate for those individuals. Ultra-sound is appropriate for patients with a likely pretest probability of DVT, an unlikely pretest probability of DVT with a positive D-dimer…

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  • Pulmonary Embolism Diagnosis & Treatment Guideline ...

    2020-9-22 · D-d i m er NEGATIVE or NONDIAGNOSTIC Likelihood of venous thromboembolism (VTE) based on D-dimer? UNLIKELY B i l at er al l o w er l i m b Do p p l er u l t r as o u n d LIKELY PE/VTE unlikely. Consider other diagnoses. POSITIVE NEGATIVE Tr eat f o r v en o u s t h r o m b o em b o l i s m . A g e-ad j u s t ed D-d i m er

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  • The DiPEP study: an observational study of the

    2018-5-21 · Sensitivities and specificities of D-dimer were 88.4% and 8.8% using a standard threshold and 69.8% and 32.8% using a pregnancy-specific threshold. Conclusions. Clinical decision rules and D-dimer should not be used to select pregnant or postpartum women …

    Get Price
  • D-dimer: Simple Test, Tough Problems | Archives of ...

    2013-8-1 · Context.—D-dimer is widely used for exclusion, or as an aid in diagnosis, of venous thromboembolism (VTE); however, the D-dimer assay methods available from manufacturers and the laboratory application of those methods vary widely.. Objectives.—To describe the current laboratory practice regarding the assay and reporting of D-dimer.. Design.—Laboratories' D-dimer proficiency …

    Get Price
  • D-dimer as a biomarker for disease severity and

    2020-7-10 · The distributions of D-dimer levels among patients with different clinical staging, chest CT staging, and who survived and deceased during hospitalization are presented in Figs. 1, 2, 3, and 4.On admission, D-dimer levels significantly increased with increasing severity of COVID-19 as determined by clinical staging (Kendall’s tau-b = 0.374, P = 0.000), chest CT staging (Kendall’s tau-b = 0 ...

    Get Price
  • Diagnosis of DVT - CHEST - American College of Chest ...

    Remarks: The choice between a moderately sensitive D-dimer test, a highly sensitive D-dimer test, or proximal CUS as the initial test will depend on local availability, access to testing, costs of testing, and the probability of obtaining a negative D-dimer result if DVT is not present. Initial testing with US would be preferred if the patient has a comorbid condition associated with elevated ...

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  • D-Dimer: Reference Range, Interpretation, Collection

    2019-11-18 · In the low-moderate group, the NPV of the D-dimer test is 99% among patients aged 60-80 years but drops to 21%-31% if the patient is older than 80 years. Similarly, D-dimer is found to be a very valuable test in pregnant patients; if a pregnant woman has a low pretest probability for DVT, the NPV of a negative D-dimer test result is 100%.

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  • Diagnosing pulmonary embolism | Postgraduate

    The test can reduce the number of imaging investigations in outpatients with a low pre-test likelihood for VTE. 7, 24– 27 However, if there is a high clinical suspicion of acute pulmonary embolism, diagnostic tests should proceed in spite of a normal D-dimer (in fact, D-dimer assay is useless in those with high clinical probability of ...

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  • Application of human factors to improve usability of ...

    If any PERC criteria are positive, a D-dimer is recommended; if all PERC criteria are negative, a PE diagnosis can be excluded without any further work-up.29 49 51 An objective of this staged diagnostic process recommended by the American College of Physicians49 is to reduce patients’ exposure to …

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  • (PDF) Diagnosis and treatment of deep-vein thrombosis

    2018-5-1 · impurities including dimer to the detector so that the analyti-cal cycle time was shortened and RT repeatability was improved. The dimer, which normally requires a second sample injection on an alternative column [3], can be possibly detected. Experimental Two configurations based on a 7890 Series GC are used in this study.

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  • Improved Gas Chromatograph Method for the Analysis of ...

    Bio-Rad offers over 10,000 antibodies, plus antigens, buffers and reagents suitable for development of research and in vitro diagnostic assays.Specificity and performance are of equal importance in the production of our antibodies.

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  • Antibodies & Antigens for Research and Diagnostic

    2021-4-26 · Zoltowski, B. D. & Crane, B. R. Light activation of the LOV protein vivid generates a rapidly exchanging dimer. Biochemistry 47 , 7012–7019 (2008). CAS PubMed Google Scholar

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